That's an interesting question!
While you can use both positive and negative indexing in the same script, you cannot combine them in a single index for a character.
For example, you can't do something like a[0 and -1] or a[0 + -1] to get a specific character. When you access a character, you provide either a single positive index (like a[0]) or a single negative index (like a[-1]). Each access needs to be a distinct index value.
Think of it like this: positive indexing counts from the left end of the string, and negative indexing counts from the right end. They both point to a specific character's position, but they are just different ways of specifying that position. You pick one way to specify the position for each character you want to access.
Does that clarify things for you? Let me know if you have more questions!